Vigilancia Tecnológica

Disclosed is a multi-stage pore hydrogel medicament sustained-release system based on natural polyphenol, which relates to the field of drug delivery. The system comprises a hydrogel matrix and a supramolecular filler. The supramolecular filler is a complex of a natural bio-based polymer and metal ions. The natural bio-based polymer is selected from one of natural polyphenol, dopamine and derivatives thereof, polysaccharide biomass and protein biomass. The hydrogel matrix is one of chitosan, carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose, hyaluronic acid, collagen, gelatin and agarose. The metal ions are one kind of cations of Al, Fe, Zn, Mn, Ni, Co and V. The supramolecular filler based on the natural bio-based polymer is formed in situ in a hydrogel, and is used for regulating and controlling pores of the hydrogel and generating interactions with different medicaments, so that the release rate of the medicament is adjusted. The supramolecular filler is low in cost and free of toxic and side effects.