DERIVATIZED COLLAGEN-HYALURONIC ACID BASED IMPLANTS FOR SUSTAINED DELIVERY OF OPHTHALMIC DRUGS
The present invention is directed to collagen-hyaluronic acid based constructs for sustained delivery of agents and drugs to ocular tissues. In certain configurations, the constructs are prepared by a method comprising combining a derivatized collagen with a hyaluronic acid. In other configurations, the constructs are prepared by a method comprising combining a hyaluronic acid-poly-L-lysine (PLL) polymer with the derivatized collagen.