Vigilancia Tecnológica

Single application of poly(tetrahydro furfuryl acrylate)?decorated microparticles to wound beds in a full thickness diabetic wound model promotes almost complete healing and tissue granulation. The wound closure, granulation tissue formation, and neovascularization are through active instruction of fibroblasts and macrophages toward pro?healing phenotypes as evidenced by changes in collagen deposition, matrix metalloproteinases expression profile, and cytokine environments.Wound healing is a complex biological process involving close crosstalk between various cell types. Dysregulation in any of these processes, such as in diabetic wounds, results in chronic nonhealing wounds. Fibroblasts are a critical cell type involved in the formation of granulation tissue, essential for effective wound healing. 315 different polymer surfaces are screened to identify candidates which actively drive fibroblasts toward either pro? or antiproliferative functional phenotypes. Fibroblast?instructive chemistries are identified, which are synthesized into surfactants to fabricate easy to administer microparticles for direct application to diabetic wounds. The pro?proliferative microfluidic derived particles are able to successfully promote neovascularization, granulation tissue formation, and wound closure after a single application to the wound bed. These active novel bio?instructive microparticles show great potential as a route to reducing the burden of chronic wounds.